allosteric regulation - significado y definición. Qué es allosteric regulation
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Qué (quién) es allosteric regulation - definición

TYPE OF REGULATION OF ENZYME ACTIVITY
Allosteric; Allosteric site; Regulatory site; Homotropic allosteric interaction; Allosteric Control; Allosteric protein; Allostery; Homotropic effect; Homotropic allosteric modulator; Allosteric inhibition; Allosterically; Heterotropic allosteric modulator; Heterotropic allosteric interaction; Homotropic modulation; Homotropic inhibition; Allosteric interaction; Allosteric model; Allosteric activation; Allostoric; Obligate activator; Allosteric control; Allosteric inhibitor; Allosteric activator; Orthosteric site
  • Inhibitor]]<br/> E – [[Enzyme]]<br/>This is a diagram of allosteric regulation of an enzyme.

allosteric         
[?al?'st?r?k, -'st??r?k]
¦ adjective Biochemistry relating to or denoting the alteration of the activity of an enzyme by means of a conformational change induced by a different molecule.
Derivatives
allosterically adverb
Allosteric modulator         
  • CX614, a PAM for an AMPA receptor binding to an allosteric site and stabilizing the closed conformation
  • Orthosteric agonist (A) binds to orthosteric site (B) of a receptor (E). Allosteric modulator (C) binds to allosteric site (D). Modulator increases/lowers the affinity (1) and/or efficacy (2) of an agonist. Modulator may also act as an agonist and yield an agonistic effect (3). Modulated orthosteric agonist affects the receptor (4). Receptor response (F) follows.
SUBSTANCE THAT BINDS TO A REGULATORY SITE DISTINCT FROM THE ACTIVE SITE ON A PROTEIN, RESULTING IN CONFORMATIONAL CHANGES THAT MAY INFLUENCE PROTEIN FUNCTION
Allosteric modulation; Positive allosteric modulator; Negative allosteric modulator; Negative allosteric modulation; Positive allosteric modulation; Positive allosteric modulators; Negative allosteric modulators; Positive modulator; Positive modulators; Negative modulator; Negative modulators
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs.
Trade regulation         
REGULATION OF TRADE PRACTICES
Trade regulation law; Trade Regulation
Trade regulation is a field of law, often bracketed with antitrust (as in the phrase “antitrust and trade regulation law”),The Florida State Bar , for example, classifies “antitrust and trade regulation law” as one of the areas of legal practice in which board certification is available, which permits certified attorneys to advertise themselves as specialists or experts. See Florida Bar.

Wikipedia

Allosteric regulation

In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.

The site to which the effector binds is termed the allosteric site or regulatory site. Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change and/or a change in protein dynamics. Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors.

Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling. Allosteric regulation is also particularly important in the cell's ability to adjust enzyme activity.

The term allostery comes from the Ancient Greek allos (ἄλλος), "other", and stereos (στερεός), "solid (object)". This is in reference to the fact that the regulatory site of an allosteric protein is physically distinct from its active site.